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Extracutaneous Merkel cell carcinoma or metastatic Merkel cell carcinoma with an occult primary?

Merkel cell carcinoma (MCC) is a rare and aggressive malignancy arising from dermal neuroendocrine cells, first described by Toker in 1972 [1]. It is predominately seen in the head and neck region of older, white males and risk factors include...

The future and a summary of the past

From liposuction to adipose stem cells; from regenerative medicine to tissue engineering; and a vision of the future. Part 3 Adipose stem cells There is a major clinical need for strategies that adequately reconstruct the soft tissue defects after deep...

A practical guide to the most commonly used dressings in wound care

The author explores and reviews the most popular classes of dressings used for acute, chronic and problem wounds, their properties and indications based on direct observation and research studies. With an ever-increasing armamentarium of wound care tools, different brands and...

How I Do It - Using Nd:Yag laser for correction of vascular anomalies

Vascular anomalies are the most common lesions that can often lead to disfigurement of a child's appearance. Due to the complexity of diagnosis and individual specialists’ understanding of their pathological process, these young patients often undergo many unnecessary tests and...

Facial Plastic and Reconstructive Surgery: Clinical Reference Guide

Plastic surgery and otolarynology are an example of two surgical specialties which intersect, allowing for clinical and research collaboration. Facial Plastic and Reconstructive Surgery: Clinical Reference Guide gives reference to a number of different principles which have been combined in...

Non-hormonal treatment options during the menopause

The author gives a comprehensive overview of prescribed treatment alternatives to hormone replacement therapy (HRT), discussing lifestyle, diet, alternative therapies, patient support and nurse education. The author argues that treatments for the symptoms of menopause are complex and that nurse...

Case-based illustration and discussion of surgical modalities to manage traumatic hand defects

The authors present four clinical cases of soft tissue defects affecting the hand and discuss various surgical management options available. These cases include a dorsal hand wound, thumb pulp defect, first webspace defect and a volar finger defect. For each...

Vascularised composite allotransplantation: an update

Vascularised composite allotransplantation (VCA) includes transplantation of multiple tissues in a single vascularised unit, such as the upper limb, or most dramatically the face. Truly remarkable results have been achieved, such as the one illustrated in this article. More than...

Could a technology from the past change skin disinfection for the future?

It wouldn’t be unreasonable to argue that the field of medicine has seen some of the most significant scientific advances of the past 100 years: the cracking of genetic coding, the advances in pharmacology, the development of biopharmaceuticals and the...

The safety of performing elective dermatological procedures under local anaesthetic during the COVID-19 pandemic

During the first wave of the COVID-19 pandemic, guidance advised postponement of elective procedures except for time-critical local anaesthetic (LA) procedures [1-3]; our NHS Trust therefore continued with LA skin malignancy surgery. All patients having possible skin cancer lesions removed...

The flora of Culloden Field: Healing plants of a wounded land

The Battle of Culloden, fought on 16 April 1746, marked the end of the Jacobite uprising in Scotland. It was a devastating clash between the Jacobite forces led by Charles Edward Stuart (‘Bonnie Prince Charlie’) and the British army under...

Handy Solutions

Very few people, if any, enjoy the ravages associated with the ageing process. Apoptosis (programmed cell death) occurs throughout life, but for some unknown reason (possibly associated with epigenetics) cellular replacement and therefore matrix volume decreases. The result is that...