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CD73 in aggressive basal cell carcinoma

This is a retrospective review looking at levels of CD73 in aggressive basal cell carcinomas (BCCs) that invade the orbit. Eleven patients who underwent orbital exenteration for invasion by BCCs were compared with 10 matched controls who had simple nodular...

Treatment of low-risk basal cell carcinoma and actinic

The first paper of this topic explored skin cancer recognition, patient education and sun safety. The second part focused on practical guidance for aesthetic nurses, should a patient present with a suspicious skin lesion. The author maintains that aesthetic nurses...

Extranodal NK/T cell lymphoma in the head and neck

The authors present a retrospective single institution review of patients with a very rare variant of non-Hodgkin lymphomas (NHL). They report on the occurrence, clinical course and outcomes of their patients with natural killer/T-cell lymphoma (NKTCL) nasal type. Sixty-three patients...

Outcomes of heavily pre-treated oral squamous cell carcinomas

Oral squamous cell carcinoma is one of the more common cancers worldwide. Surgery is the mainstay of treatment and often these patients have had adjuvant therapies. In spite of improving five year survival rates, local recurrent progressive disease is still...

Postoperative follow-up of oral squamous cell carcinoma: a new protocol

Oral and oropharyngeal cancers together are the sixth most common malignancy in the world, with an increasing incidence of oral squamous cell carcinoma (OSCC). The recurrence rate of OSCC is reported to be approximately 10-26%. About two-thirds of all recurrent...

PD-1 and PD-L1 in exenteration specimens

This is an immunohistochemical study looking at variation in the expression of the programmed death-1 receptor (PD-1) and the programmed cell death ligand-1 (PD-L1), comparing cutaneous malignancies which invaded the orbit with uncomplicated nodular basal cell carcinomas. The authors retrospectively...

Stem cells in reconstructive surgery: a bright but cautious future

Regenerative medicine using stem cell technology is slowly becoming a reality in routine clinical practice especially in the field of tissue regeneration [1]. It is therefore not surprising that stem cell technology is starting to be of interest in reconstructive...

New approaches to soft tissue reconstruction involving adipose tissue engineering

Introduction The spectrum of patients affected by subcutaneous tissue loss is both wide and varied, including those who have undergone tumour removal, trauma patients, such as those injured in road traffic accidents, and individuals who have suffered from deep burns...

Allogenic submandibular gland transplantation

The authors discuss and report success with an elegant but difficult solution to a difficult problem. Dry eyes are a difficult problem and incidence increases with age. It can lead to severe reduction in the quality of life of patients....

Bioengineered human tissue

This is a literature review of the current status of tissue engineering related to ocular and oculoplastic reconstructive surgery. The authors describe the process of bioengineering for tissue reconstruction. The aim is to reproduce functional tissue by the use of...

The use of platelet-rich plasma in skin flap grafts

This study was conducted to evaluate the ability of platelet rich plasma (PRP) to stimulate angiogenesis following skin flaps graft surgery, and its effect on flap survival rate. The use of PRP to improve the quality of bone regeneration and...