Tranexamic acid and blood loss in bimaxillary surgery
Reviewed by Stuart Clark

This is a randomised, double blind, placebo-controlled trial from Thailand to clarify the most effective dose of Tranexamic acid in reducing blood loss during a bimaxillary osteotomy. They confirmed that the dose of 10mg per kg is the most efficacious and cost-effective. Nonetheless, there is no significant difference in transfusion requirement, amount of drainage or length of hospital stay. One could conclude therefore, outwith unexpected untoward haemorrhage, there is no practical benefit in giving it.

The effect of different dosage regimes of tranexamic acid and blood loss in bi-maxillary osteotomy of randomised double blind placebo controlled study.
Apipan B, Rummasak D, Narainthonsaenee T.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
2018;47:608-12.