This study was conducted to evaluate the ability of platelet rich plasma (PRP) to stimulate angiogenesis following skin flaps graft surgery, and its effect on flap survival rate.
The use of PRP to improve the quality of bone regeneration and soft tissue reconstruction has been suggested in literature previously, however, there is a lack of scientific evidence to support the use of PRP in combination with skin flap grafts. An experimental rabbit model was used to compare the effect of PRP versus saline when injected into the flap basal surface. Histological examination and immuno-histochemical analysis was used to determine the extent of angiogenesis and inflammatory cell infiltration. Flap survival rates were measured using standardised digital photograph and scion image software to calculate the percentage of survival area compared with the total skin flap area. The results provided evidence to support the authors’ hypothesis that PRP injection improves survival rate of a flap through neovascularisation and reduction of inflammatory cell infiltration. The mechanism by which this occurs is not yet clear and warrants further research. The study presents promising evidence to support the further use of PRP in skin flap surgery.

Platelet-rich plasma reduces skin flap inflammatory cells infiltration and improves survival rates through induction of angiogenesis: an experiment in rabbits.
Wang B, Geng Q, Hu J, et al.
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Clara Smith

NHS Greater Glasgow & Clyde, UK

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