The author provides a detailed review of the available evidence regarding the concept of biorevitalisation. A detailed discussion of injectable ingredients used to rejuvenate the skin is explored, with an overview of the history of hyaluronic acid along with a definition of this core ingredient which constitutes a growing number of dermal filler formulations. The author differentiates biorevitalisation, from the technique of mesotherapy, describing it as a treatment used to rejuvenate the skin by means of transdermal injections of multivitamin solutions and natural plant extracts that are thought to improve the signs of skin ageing. A variety of polycomponent products are used, for example, vitamins A, C and E, amino acids, flavonoids, coenzymes and antioxidants. The author critiques a promising, albeit small, but growing body of literature which shows improvements in skin complexion, an increase in collagen type 1 gene expression as well as elastin gene expression, and improvements to skin hydration. Equally, biorevitalisation formulas may vary greatly between fabricants, which accounts for some variants in the literature. Ultimately the exponential growth in the demand and number of non-surgical procedures being performed has meant that the types of treatments on offer has subsequently increased, with biorevitalisation using mesotherapy technique, as one example. A thorough and interesting review of the current literature for aesthetic nurses with an interest in mesotherapy.